研究報告

SANK70258の研究報告

Human, mouse

No.	Study Date	Study	Benefit Studied	Ref.
1	1997	The effects of spore-forming lactic acid bacteria (Bacillus coagulans) in improving human intestinal bacterial flora	Gut health	Progress in Medicine Vol.17 No.12 3303（1997）
		Study Type : Open-Label study 　Sample Size : 18 　Study Duration (Days) : 2 weeks 　Dose : 20 million cfu, 100 million 200 million cfu/day,
2	1997	The effects of spore-forming lactic acid bacteria (Bacillus coagulans) in improving the properties of feces	Improve fecal conditions such as color, shape, discomfort, odor, Bowel movement	Progress in Medicine　Vol.17 No.12 3299（1997）
		Study Type : Open-Label study 　Sample Size : 28 　Study Duration (Days) : 2 weeks 　Dose : 100 million cfu/day
3	2002	Effect of Spore-bearing Lactic Acid-forming Bacteria (Bacillus coagulans SANK 70258) Adminstrtion on the Intestinal Environment, Defecation Frequency, Fecal Characteristics and Dermal Characteristics in Humans and Rats	Bowel Movement/Gut health	Microbial Ecology in Health and Disease 2002; 14: 4–13
		Study Type : Open-Label study Sample Size : 20 healthy men/women Subject Age : 20-40 Study Duration (Days) : 2 weeks Dose : 100 million cfu/day
4	2002	Effect of Spore-bearing Lactic Acid-forming Bacteria (Bacillus coagulans SANK 70258) Adminstrtion on the Intestinal Environment, Defecation Frequency, Fecal Characteristics and Dermal Characteristics in Humans and Rats	Skin	Microbial Ecology in Health and Disease 2002; 14: 4–13
		Study Type : Open-Label study Sample Size : 23 health women Subject Age : 20-40 Study Duration (Days) : 4 weeks Dose : 100 million cfu/day
5	2005	Effect of Bacillus Coagulans SANK 70258 on Seasonal Allergic Rhinitis	Allergic Rhinitis	Journal of New Remedies & Clinics, Vol. 54, No. 11, 2005
		Study Type : Randomized, Double-Blind, Placebo-Controlled study Sample Size : 60 healthy men/women with infrequent bowel movements Subject Age : 20-64 Study Duration (Days) : 2 weeks Dose : 100 million cfu/day
6	2018	Effects of Intake of Bacllis coagulans SANK 70258, "Spore-forming Lactic Acid Bacteria", on Bowel Movement in Healthy Volunteers - A Randomized, Double-Blind, Place-Controlled, Parallel Group Study	Bowel Movement	Japanese Pharmacology & Therapeutics 46, 9, 1549-1558 (2018)
		Study Type : Randomized, Double-Blind, Placebo-Controlled study Sample Size : 58 healthy men/women with cedar pollen allergy Subject Age : 20-65 Study Duration (Days) : 8 weeks Dose : 400 million cfu/day
7	2020	Bacillus Coagulans SANK 70258 Suppresses Enterobacteriaceae in the Microbiota of Ulcerative Colitis in Vitro and Enhances Butyrogenesis in Health Microbiota	Increase Butyric acid	Applied Microbiology and Biotechnology (2020) 104:3859–3867
		Study Type : In vitro microbiota model Sample Size : 8 ulcerative colitis patients and 7 healthy adults Dose : 40 million cells/ml *Initial concentration
8	2023	Weizmannia coagulans strain SANK70258 combined with galacto-oligosaccharides reduces fecal-p-cresol content and improves scaliness and skin	Skin scaliness, Skin roughness, gut health	Journal of Functional Foods 107 (2023) 105665
		Study Type : Randomized, Double-Blind, Placebo-Controlled study Sample Size : 45 healthy women with infrequent bowel movements Subject Age : 30-50 Study Duration (Days) : 8 weeks Dose : 400 million cfu/day, GOS:2.5g
9	2024	Improvement of Skin Condition and Intestinal Flora via Heyndrickxia coagulans SANK70258 Intake: A Placebo-Controlled, Randomized, Double-Blind, Parallel-Group Comparative Study	Immune, Gut health (butyric acid increase)	Front. Immunol., 17 June 2024 Sec. Nutritional Immunology Volume 15 - 2024
		Study Type : Randomized, Double-Blind, Placebo-Controlled study Sample Size : 80 healthy men/women Subject Age : 20-65 Study Duration (Days) : 8 weeks Dose : 1 billion cfu/day
10	2024	Improvement of Skin Condition and Intestinal Flora via Heyndrickxia coagulans SANK70258 Intake: A Placebo-Controlled, Randomized, Double-Blind, Parallel-Group Comparative Study	Skin brightness, Skin scaliness, Gut health	Nutrition Volume 126, October 2024, 112533
		Study Type : Randomized, Double-Blind, Placebo-Controlled study Sample Size : 80 healthy women with perceived skin roughness Subject Age : 30-65 Study Duration (Days) : 8 weeks Dose : 1 billion cfu/day
11	2024	Immunostimulatory effects of Heyndrickxia coagulans SANK70258	Immunomodulatary effect	Bioscience, Biotechnology, and Biochemistry, 2025, 89, 622–632
		Study Type : mouse model study
12	2024	Combination of probiotics enhancing butyrogenesis in colonic microbiota model of patients with ulcerative colitis	Increase Butyric acid	Applied Microbiology and Biotechnology (2025) 109:117
		Study Type : In vitro microbiota model Sample Size : 7 ulcerative colitis patients Dose : 400 million cells/ml
13	2025	Immunomodulatory effect of Heyndrickxia coagulans strain SANK70258 via intestinal microbiota: post-hoc analysis of a randomized, double-blind, placebo-controlled, parallel-group comparative study	Immune, Gut health(butyric acid increase)	Under review
		Study Type : Randomized, Double-Blind, Placebo-Controlled study Sample Size : 80 healthy men/women Subject Age : 20–65 Study Duration (Days) : 8 weeks Dose : 1 billion cfu/day

Live stock

No.	Study Date	Study	Benefit Studied	Ref.
1	2022	Noninvasive fecal metabolic profiling for the evaluation of characteristics of thermostable lactic acid bacteria, Weizmannia coagulans SANK70258, for broiler chickens	microbial modulation increase short chain fatty acid	Journal of Bioscience and Bioengineering Volume 134, Issue 2, August 2022, Pages 105-115
		Study Type : Broiler chikens Sample Size : 28 Study Duration (Days) : 21days Dose : administered in the drinking water at a concentration of at least 106 CFU/ml as the final concentration by ad libitum drinking for the first 10 days and thereafter at least 106 CFU/g as the final concentration of a feed additive.
2	2022	The Effect of Supplementation with Weizmannia coagulans Strain SANK70258 to Coccidia-Infected Broilers Is Similar to That of a Coccidiostat Administration	Prevention of infectious diseases Gut health	Veterinary science. 2022, 9(8), 406
		Study Type : Broiler chikens Sample Size : 20 Study Duration (Days) : 31days Dose : given feed supplemented with 3×105CFU/g ad libitum.
3	2023	Dietary Weizmannia coagulans Strain SANK70258 Ameliorates Coccidial Symptoms and Improves Intestinal Barrier Functions of Broilers by Modulating the Intestinal Immunity and the Gut Microbiota	Prevention of infectious diseases Gut health	Pathogens 2023, 12(1), 96
		Study Type : Broiler chikens Sample Size : 20 Study Duration (Days) : 31days Dose : given feed supplemented with 3×105CFU/g ad libitum.
4	2024	Exploring spore-forming lactic acid bacterium Heyndrickxia coagulans SANK70258 as a promising probiotic for red sea bream (Pagrus major)	Gut health	Front. Aquac., 22 November 2024
		Study Type : red sea bream (Pagrus major) Sample Size : 4800 Study Duration (Days) : 63days Dose : The concentration of H. coagulans SANK70258 was maintained at 108 colony-forming units (cfus/g feed)
5	2025	Dietary administration of Heyndrickxia coagulans SANK 70258 enhances the growth performance of growing pigs via the improvement of leaky gut and liver function.	Gut health	Front. Vet. Sci., 27 May 2025
		Study Type : pig Sample Size : 24 Study Duration (Days) : 126days Dose : Supplementation was given to groups at 0.01% (w/w), so that diets contained 1 × 105 CFU per g of feed (0.1g/kg of feed)

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